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Exosomal CD44 Cooperates with Integrin α6β4 to Support Organotropic Metastasis via Regulating Tumor Cell Motility and Target Host Cell Activation Article

Wei Mu, Yajie Xu, Pengfei Gu, Wenbo Wang, Jingquan Li, Yang Ge, Hui Wang

Engineering 2021, Volume 7, Issue 10,   Pages 1415-1425 doi: 10.1016/j.eng.2020.08.013

Abstract: membrane, supporting the reprogramming of the tumor microenvironment and the progression of distant metastatichas demonstrated that CD44, a transmembrane glycoprotein delivered by exosomes, is involved in the metastaticuptake of CD44-competent tumor exosomes by liver cells activated fibrotic pathways and generated a pre-metastaticniche by stimulating the cytokines, proinflammatory factors, and growth factors that ultimately support

Keywords： Pancreatic cancer     Organotropic metastasis     Exosomes     Pre-metastatic niche     CD44    

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Coupling of the chemical niche and microbiome in the rhizosphere: implications from watermelon grafting

Yang SONG, Chen ZHU, Waseem RAZA, Dongsheng WANG, Qiwei HUANG, Shiwei GUO, Ning LING, Qirong SHEN

Frontiers of Agricultural Science and Engineering 2019, Volume 6, Issue 2,   Pages 206-206 doi: 10.15302/J-FASE-2018234

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Association of SIPA1 545 C>T polymorphism with survival in Chinese women with metastatic breast cancer

Renling Pei, Ye Xu, Yan Wei, Tao Ouyang, Jinfeng Li, Tianfeng Wang, Zhaoqing Fan, Tie Fan, Benyao Lin, Yuntao Xie

Frontiers of Medicine 2013, Volume 7, Issue 1,   Pages 138-142 doi: 10.1007/s11684-013-0247-5

Abstract: polymorphisms (SNPs) of SIPA1 (signal-induced proliferation associated gene 1) are associated with metastaticwhether SIPA1 545 C>T polymorphism was associated with overall survival in patients with metastaticIn this study, SIPA1 545 C>T polymorphism was detected in 185 metastatic breast cancer patients;SIPA1 545 C>T polymorphism was significantly associated with survival in 185 patients with metastaticOur findings indicate that metastatic breast cancer patients with SIPA1 545 T/T genotype have

Keywords： SIPA1     polymorphism     metastatic breast cancer     survival    

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Establishment and drug sensitivity evaluation of murine ascites hepatocarcinoma cell line with high lymphatic metastatic

Hongying ZHANG, Jianwu TANG, Wenting ZHU, Chunxiu HU, Guowang XU

Frontiers of Medicine 2009, Volume 3, Issue 2,   Pages 119-129 doi: 10.1007/s11684-009-0022-9

Abstract: effect of medicine against cells, a new murine ascites hepatocarcinoma cell line with high lymphatic metastaticMurine ascites hepatocarcinoma cell strain with low lymphatic metastatic potential (Hca-P) was subcutaneouslyinoculated into the medioventral line of a mouse 615 and the first generation of metastatic tumor cellsThe lymph node metastatic rate was 100%.

Keywords： murine ascites hepatocarcinoma cell line     metastasis     curcumin     drug sensitivity    

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treatment is associated with improved survival and increased response to immune checkpoint blockade in metastatic

Frontiers of Medicine   Pages 878-888 doi: 10.1007/s11684-023-0993-y

Abstract: A total of 182 patients with metastatic UM treated with immune checkpoint blockade (ICB) were includedICB may be associated with a survival benefit and higher treatment response to ICB in patients with metastatic

Keywords： uveal melanoma     liver-directed therapy     immune checkpoint blockade     SIRT     anti-PD-1     anti-CTLA-4    

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Stem cell niches and endogenous electric fields in tissue repair

Li LI, Jianxin JIANG

Frontiers of Medicine 2011, Volume 5, Issue 1,   Pages 40-44 doi: 10.1007/s11684-011-0108-z

Abstract: Endogenous adult stem cells reside in certain regions of organs, known as the stem cell niche, whichelectric fields in tissue repair, and hypothesize that endogenous electric fields become part of stem cell niche

Keywords： stem cell     stem cell niche     electric field     tissue repair    

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Nonlinear analysis of pre-tensioned glass wall facade by stability function with initial imperfection

Siu-Lai CHAN, Yaopeng LIU, Andy LEE,

Frontiers of Structural and Civil Engineering 2010, Volume 4, Issue 3,   Pages 376-382 doi: 10.1007/s11709-010-0086-2

Abstract: Pre-tensioned high strength trusses using alloy steel bar are widely used as glass wall supporting systemsvarious effects, such as support settlement due to live loads and material creep, temperature change, pre-tension

Keywords： tension system     glass wall     nonlinear analysis     pre-tensioning     second-order analysis    

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Neoadjuvant radiohormonal therapy for oligo-metastatic prostate cancer: safety and efficacy outcomes

Frontiers of Medicine 2023, Volume 17, Issue 2,   Pages 231-239 doi: 10.1007/s11684-022-0939-9

Abstract: To evaluate the safety and efficacy of neoadjuvant radiohormonal therapy for oligometastatic prostate cancer (OMPC), we conducted a 3 + 3 dose escalation, prospective, phase I/II, single-arm clinical trial (CHiCTR1900025743), in which long-term neoadjuvant androgen deprivation was adopted 1 month before radiotherapy, comprising intensity modulated radiotherapy to the pelvis, and stereotactic body radiation therapy to all extra-pelvic bone metastases for 4‒7 weeks, at 39.6, 45, 50.4, and 54 Gy. Robotic-assisted radical prostatectomy was performed after 5‒14 weeks. The primary outcome was treatment-related toxicities and adverse events; secondary outcomes were radiological treatment response, positive surgical margin (pSM), postoperative prostate-specific antigen (PSA), pathological down-grading and tumor regression grade, and survival parameters. Twelve patients were recruited from March 2019 to February 2020, aging 66.2 years in average (range, 52‒80). Median baseline PSA was 62.0 ng/mL. All underwent RARP successfully without open conversions. Ten patients recorded pathological tumor down-staging (83.3%), and 5 (41.7%) with cN1 recorded negative regional lymph nodes on final pathology. 66.7% (8/12) recorded tumor regression grading (TRG) –I and 25% (3/12) recorded TRG-II. Median follow-up was 16.5 months. Mean radiological progression-free survival (RPFS) was 21.3 months, with 2-year RPFS of 83.3%. In all, neoadjuvant radiohormonal therapy is well tolerated for oligometastatic prostate cancer.

Keywords： neoadjuvant     radiotherapy     oligometastatic     prostate cancer     radical prostatectomy    

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A pre-compensation method of the systematic contouring error for repetitive command paths

D. L. ZHANG,Y. H. CHEN,Y. P. CHEN

Frontiers of Mechanical Engineering 2015, Volume 10, Issue 4,   Pages 367-372 doi: 10.1007/s11465-015-0367-5

Abstract:

For a repetitive command path, pre-compensating the contouring error by modifying the command pathTo obtain the pre-compensation value with better accuracy, this paper proposes the use of a back propagationFurthermore, by using the extracted function, the contouring error can be easily pre-compensated.

Keywords： contouring error     pre-compensation     motion control system     back propagation (BP) neural network    

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Experimental and parametrical investigation of pre-stressed ultrahigh-performance fiber-reinforced concrete

Frontiers of Structural and Civil Engineering 2023, Volume 17, Issue 3,   Pages 411-428 doi: 10.1007/s11709-023-0928-3

Abstract: In this study, ultrahigh-performance fiber-reinforced concrete (UHPFRC) used in a type B70 concrete sleeper is investigated experimentally and parametrically. The main parameters investigated are the steel fiber volume fractions (0%, 0.5%, 1%, and 1.5%). Under European standards, 35 UHPFRC sleepers are subjected to static bending tests at the center and rail seat sections, and the screw on the fastening system is pulled out. The first cracking load, failure load, failure mode, crack propagation, load–deflection curve, load–crack width, and failure load from these tests are measured and compared with those of a control sleeper manufactured using normal concrete C50. The accuracy of the parametric study is verified experimentally. Subsequently, the results of the study are applied to UHPFRC sleepers with different concrete volumes to investigate the effects of the properties of UHPFRC on their performance. Experimental and parametric study results show that the behavior of UHPFRC sleepers improves significantly when the amount of steel fiber in the mix is increased. Sleepers manufactured using UHPFRC with a steel fiber volume fraction of 1% and a concrete volume less than 25% that of standard sleeper B70 can be used under the same loads and requirements, which contributes positively to the cost and surrounding environment.

Keywords： pre-stressed concrete sleeper     ultrahigh performance fiber-reinforced concrete     pull-out test     static    

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Investigation into viability of using two-stage (pre-placed aggregate) concrete in Irish setting

John O’MALLEY, Hakim S. ABDELGADER,

Frontiers of Structural and Civil Engineering 2010, Volume 4, Issue 1,   Pages 127-132 doi: 10.1007/s11709-010-0007-4

Abstract: Two-stage (pre-placed aggregate) concrete (TSC) consists of coarse aggregate, which is first deposited

Keywords： grout     pre-placed     concrete     two-stage concrete (TSC)    

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Optimization of denitrifying phosphorus removal in a pre-denitrification anaerobic/anoxic/post-aeration+ nitrification sequence batch reactor (pre-A

Weihua Zhao, Meixiang Wang, Jianwei Li, Yu Huang, Baikun Li, Cong Pan, Xiyao Li, Yongzhen Peng

Frontiers of Environmental Science & Engineering 2018, Volume 12, Issue 5, doi: 10.1007/s11783-018-1084-1

Abstract:

A novel two sludge pre-A2NSBR system was developed.

Keywords： Denitrifying phosphorus removal     C/N ratio     Nitrate recycling     Carbon source type     Biological nutrient removal     Pre-A    

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Evaluation of the static and dynamic structural performance of segmental pre-stressed concrete box girder

Ali Fadhil NASER, Zonglin WANG

Frontiers of Structural and Civil Engineering 2013, Volume 7, Issue 2,   Pages 164-177 doi: 10.1007/s11709-013-0196-8

Abstract: side spans by sticking the steel plates, strengthening the whole bridge structure by using external pre-stressing

Keywords： structural performance     steel plates     external pre-stressing     cracks     grouting method     static    

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Techno-economic comparison of three technologies for pre-combustion CO

Simon Roussanaly, Monika Vitvarova, Rahul Anantharaman, David Berstad, Brede Hagen, Jana Jakobsen, Vaclav Novotny, Geir Skaugen

Frontiers of Chemical Science and Engineering 2020, Volume 14, Issue 3,   Pages 436-452 doi: 10.1007/s11705-019-1870-8

Abstract: This paper compares the techno-economic performances of three technologies for CO capture from a lignite-based IGCC power plant located in the Czech Republic: (1) Physical absorption with a Rectisol-based process; (2) Polymeric CO -selective membrane-based capture; (3) Low-temperature capture. The evaluations show that the IGCC plant with CO capture leads to costs of electricity between 91 and 120 €·MWh , depending on the capture technology employed, compared to 65 €·MWh for the power plant without capture. This results in CO avoidance costs ranging from 42 to 84 €· , mainly linked to the losses in net power output. From both energy and cost points of view, the low-temperature and Rectisol based CO capture processes are the most efficient capture technologies. Furthermore, partial CO capture appears as a good mean to ensure early implementation due to the limited increase in CO avoidance cost when considering partial capture. To go beyond the two specific CO -selective membranes considered, a cost/membrane property map for CO -selective membranes was developed. This map emphasise the need to develop high performance membrane to compete with solvent technology. Finally, the cost of the whole CCS chain was estimated at 54 €· once pipeline transport and storage are taken into consideration.

Keywords： carbon capture and storage (CCS)     techno-economic comparison     pre-combustion capture     physical solvent     low-temperature    

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Hybrid flexural components: Testing pre-stressed steel and GFRP bars together as reinforcement for flexural

Mohammed FARUQI, Oved I. MATA, Francisco AGUINIGA

Frontiers of Structural and Civil Engineering 2018, Volume 12, Issue 3,   Pages 352-360 doi: 10.1007/s11709-017-0453-3

Abstract:

Concrete members historically have used either pre-stressed steel or steel bars.However, the flexure behavior of a hybrid system reinforced by the combination of pre-stressed steelTwo slabs of 100 and 150-millimeter thickness, with a span of 2.1 m reinforced with both pre-stressingThe theoretical slabs were either reinforced with pre-stressed steel or GFRP rebars, or a hybrid system

Keywords： Partial pre-stressing     composite structures     GFRP bars    

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Title Author Date Type Operation

Exosomal CD44 Cooperates with Integrin α6β4 to Support Organotropic Metastasis via Regulating Tumor Cell Motility and Target Host Cell Activation

Wei Mu, Yajie Xu, Pengfei Gu, Wenbo Wang, Jingquan Li, Yang Ge, Hui Wang

Journal Article

Coupling of the chemical niche and microbiome in the rhizosphere: implications from watermelon grafting

Yang SONG, Chen ZHU, Waseem RAZA, Dongsheng WANG, Qiwei HUANG, Shiwei GUO, Ning LING, Qirong SHEN

Journal Article

Association of SIPA1 545 C>T polymorphism with survival in Chinese women with metastatic breast cancer

Renling Pei, Ye Xu, Yan Wei, Tao Ouyang, Jinfeng Li, Tianfeng Wang, Zhaoqing Fan, Tie Fan, Benyao Lin, Yuntao Xie

Journal Article

Establishment and drug sensitivity evaluation of murine ascites hepatocarcinoma cell line with high lymphatic metastatic

Hongying ZHANG, Jianwu TANG, Wenting ZHU, Chunxiu HU, Guowang XU

Journal Article

treatment is associated with improved survival and increased response to immune checkpoint blockade in metastatic

Journal Article

Stem cell niches and endogenous electric fields in tissue repair

Li LI, Jianxin JIANG

Journal Article

Nonlinear analysis of pre-tensioned glass wall facade by stability function with initial imperfection

Siu-Lai CHAN, Yaopeng LIU, Andy LEE,

Journal Article

Neoadjuvant radiohormonal therapy for oligo-metastatic prostate cancer: safety and efficacy outcomes

Journal Article

A pre-compensation method of the systematic contouring error for repetitive command paths

D. L. ZHANG,Y. H. CHEN,Y. P. CHEN

Journal Article

Experimental and parametrical investigation of pre-stressed ultrahigh-performance fiber-reinforced concrete

Journal Article

Investigation into viability of using two-stage (pre-placed aggregate) concrete in Irish setting

John O’MALLEY, Hakim S. ABDELGADER,

Journal Article

Optimization of denitrifying phosphorus removal in a pre-denitrification anaerobic/anoxic/post-aeration+ nitrification sequence batch reactor (pre-A

Weihua Zhao, Meixiang Wang, Jianwei Li, Yu Huang, Baikun Li, Cong Pan, Xiyao Li, Yongzhen Peng

Journal Article

Evaluation of the static and dynamic structural performance of segmental pre-stressed concrete box girder

Ali Fadhil NASER, Zonglin WANG

Journal Article

Techno-economic comparison of three technologies for pre-combustion CO

Simon Roussanaly, Monika Vitvarova, Rahul Anantharaman, David Berstad, Brede Hagen, Jana Jakobsen, Vaclav Novotny, Geir Skaugen

Journal Article

Hybrid flexural components: Testing pre-stressed steel and GFRP bars together as reinforcement for flexural

Mohammed FARUQI, Oved I. MATA, Francisco AGUINIGA

Journal Article